Mapurosesa angapo azakudya amapanga zitsanzo zowumitsidwa bwino kwambiri pamagawo ang'onoang'ono oyendetsa R&D. Komabe, atasinthira ku zowumitsira zowumitsa zazikulu zamafakitale kuti apange zochuluka, amakumana ndi kugwa, kuyanika kosafanana, kuchepa kwa rehydration ratio komanso kupatuka kwakukulu kwa batch-to-batch, komwe kumadziwika kuti "freeze-drying" "scale-up effect". Makina opanga ma lab-scale ndi opanga amagwira ntchito mosiyanasiyana; magawo oyesa oyendetsa sangathe kukopera mwachindunji pamagawo akulu opanga.
Choyamba, kusiyana kofanana kwa alumali ndi kutentha. Zipinda zoyesera zazing'ono zimakhala ndi zopatuka pa shelufu ya kutentha. Zipinda zazikulu zowumitsa zowumira zamafakitale zimakhala ndi kuchuluka kwakukulu, ndipo kusiyana kwa kutentha kumakhala pakati pa malo apakati ndi ngodya. Ndi kutentha komweko, mawanga omwe ali mkati mwa zipinda zazikulu amafika kutentha kwenikweni ndikuyambitsa kusungunuka ndi kugwa. Popanga masinthidwe, kutentha kwa shelufu kuchepetsedwa pang'onopang'ono ndikusunga-nthawi kuti athe kubwezera kutentha kwapatuka.
Chachiwiri, kusiyana kwa vacuum-system ndi kutengera madzi. Makina oyesa oyesa amanyamula katundu wocheperako ndipo amatulutsa mpweya wocheperako pang'ono wamadzi. Zipangizo zodzaza mokwanira zimatulutsa nthunzi wambiri wamadzi pakanthawi kochepa, zomwe zimapangitsa kuti pakhale kufunikira kwakukulu pakugwira madzi a msampha wozizira komanso kuchuluka kwa vacuum-pampu. Kutengera mwachindunji magawo a oyendetsa-vacuum kumabweretsa kusakwanira kwa nthunzi ndi kusinthasintha kwa vacuum mkati mwa chipinda, ndikusokoneza kayimbidwe ka sublimation. Popanga zambiri, yang'anani kutentha kwenikweni kwa msampha m'malo mongowerenga zomwe zakhazikitsidwa.
Chachitatu, kachulukidwe kachulukidwe ndi kachulukidwe ka thireyi. Mayesero oyendetsa ma labu nthawi zambiri amatenga zinthu zoonda komanso zotsika kwambiri. Kuti muwonjezere zokolola m'mafakitole enieni, zigawo zokulirapo komanso zodzaza kwambiri zimagwiritsidwa ntchito. Kuchuluka-kukhuthala kumatalikitsa njira yoyatsira nthunzi yakunja; Kuzungulira kwa sublimation kuyenera kukulitsidwa moyenerera, apo ayi gawo lapakati lazinthu likhalebe louma. Werenganinso mapindikidwe okhazikika athunthu malinga ndi makulidwe enieni a kachulukidwe, osagwiritsanso ntchito magawo a nthawi kuchokera ku mayeso oyendetsa ndege osanjikiza.
Chachinayi, kusiyana kozungulira. Zipinda zoyesera za labu zimasunga kutentha kosasintha & chinyezi; zokambirana zenizeni zimakhala ndi kusinthasintha kwa nyengo komwe kumakhudza kutulutsa kwenikweni kwa firiji. M'nyengo yotentha yachilimwe, kuzizira kwenikweni kumatsika pansi pazikhazikiko zomwezo, zomwe zimafuna kukonzedwa bwino kwa magawo oziziritsa ndi kuzizira.
Mfundo zolondola zokulirapo: zoyeserera zoyeserera zimangotsimikizira kuthekera kwazinthu ndi zomwe zimachitika ndipo sizidzatengedwa ngati miyezo yopangira. Mukapeza zoyeserera zoyeserera, chitani zotsimikizira za woyendetsa wapakati kaye ndikubwereza magawo pang'onopang'ono pofikira kupanga zochuluka. Unikaninso kuziziritsa kusanachitike, kutsitsa ndi desorption-kuyanika mbiri yokhazikika molingana ndi magwiridwe antchito enieni a zida zopangira, kuti muthe kutengera mosalekeza zabwino za zitsanzo zamayesero a labu.
